C57BL/10-mdx mice were backcrossed to DBA/2J inbred mice for several generations by Jackson Labs, using a speed congenics approach to generate the DBA/2J-congenic strain (DBA/2J-mdx). The skeletal muscle and cardiac phenotype is more severe than that of C57BL/10ScSn-Dmdmdx/J. This may be a useful model for preclinical drug testing. DBA2/J mice are the wild-type controls for this model. We have systematically phenotyped this model at multiple age groups.
Coley, W. D., Bogdanik, L., Vila, M. C., Yu, Q., Van Der Meulen, J. H., Rayavarapu, S., . . . Nagaraju, K. (2016). Effect of genetic background on the dystrophic phenotype in mdx mice. Human Molecular Genetics, 25(1), 130-145. doi:10.1093/hmg/ddv460. Publication
Fukada, S., Morikawa, D., Yamamoto, Y., Yoshida, T., Sumie, N., Yamaguchi, M., … Yamamoto, H. (2010). Genetic Background Affects Properties of Satellite Cells and mdx Phenotypes. The American Journal of Pathology, 176(5), 2414–2424. Publication