Crossbreeding TRE-H2Kb and CRE-tTA produces the mouse model of myositis (the HT mouse model), which can result in muscle weakness in the mice. The onset of disease can be controlled by administering doxycycline (0.2g/L) in the drinking water of the animals. Muscle weakness is readily apparent in female mice by 3 months of age, while males show fewer signs of disease onset. Signs of the disease onset include muscle weakness and reduced locomotor activity.
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Alger, H. M., Raben, N., Pistilli, E., Francia, D., Rawat, R., Getnet, D., … Nagaraju, K. (2011). The role of tumor necrosis factor-α-related apoptosis-inducing ligand (TRAIL) in mediating autophagy in myositis skeletal muscle: A potential non-immune mechanism of muscle damage. Arthritis and Rheumatism, 63(11), 3448–3457. Publication
Coley, W., Rayavarapu, S., van der Meulen, J. H., Duba, A. S., & Nagaraju, K. (2013). Daily Supplementation of D-ribose Shows No Therapeutic Benefits in the MHC-I Transgenic Mouse Model of Inflammatory Myositis. PLoS ONE, 8(6), e65970. Publication
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