Services

AGADA Biosciences offers in vivo and in vitro preclinical efficacy studies with a broad range of available phenotyping measures and endpoints with adherence to best practices. Data from seven years of preclinical trial experience is available for normative values and benchmarking in multiple mouse models of neuromuscular disease (over 1 million data points).

 

Available services:

  • Treadmill exercise challenge
  • Exhaustion assay
  • Grip strength measurements 
  • Voluntary wheel running assessments
  • Micro-echocardiography (cardiac function)
  • Plethysmography (lung function)
  • Rotarod performance test
  • Muscle physiology testing 
    • Maximal force measurement
    • Specific force measurement
    • Fatigue protocol
    • Lengthening contraction protocol
  • Pharmacodynamic biomarker panels
  • Hematoxylin and eosin (H&E) histology
  • Fibrosis quantitation
  • Immunohistochemistry 
  • Evans blue dye in vivo muscle labeling
  • Protein RNA and DNA extractions from tissues
    • Western blotting
    • Quantitative mass spectrometry 
    • RT-PCR 
  • Cell-based in vitro assays for drug activity 

 

AGADA Biosciences can implement custom services upon request.

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